Professore Associato in Anatomia degli Animali Domestici presso il Dipartimento di Scienze Veterinarie, Università di Teramo. L’esperienza scientifica accumulata in differenti laboratori di ricerca italiani ed esteri caratterizza il docente Domenico Iuso come un ricercatore multidisciplinare con una particolare attenzione ai risvolti morfo-funzionali determinati da modificazioni epigenetiche. Interesse di ricerca: studio delle dinamiche epigenetiche che indirizzano la differenziazione cellulare, morfologica e funzionale, durante lo sviluppo embrionale.

Formazione

2022 Associate Professore Associato in Anatomia degli Animali Domestici, Dipartimento di Scienze Veterinarie, Università di Teramo, Teramo, Italia. 

2021 Abilitazione Scientifica Nazionale alle funzioni di Professore Universitario di Seconda Fascia nel Settore Concorsuale 07/H1.

2009-2012: 14.11.2012 - Dottorato di Ricerca in Embriologia Sperimentale, Università di Teramo, Italia. 

2007-2009: 12-10-2009 - Laurea Specialistica in Biotecnologie della Riproduzione, Università di Teramo, Italia.

2004-2007: 08-10-2007 - Laurea triennale in Biotecnologie BSc Biotechnologies, Università di Teramo, Italia. 

Attività di Ricerca

-Ottobre 2022-posizione corrente: Professore Associato in Anatomia degli Animali Domestici, Dipartimento di Scienze Veterinarie, Università di Teramo, Italia. 

-Aprile 2017- Febbraio 2022: Ricercatore PostDoc, Institute for Advanced Biosciences (IAB), University of Grenoble Alpes, Grenoble, Francia- Institute of Structural Biology (IBS), Grenoble Alpes , France.

-Gennaio 2016- Marzo 2017: Ricercatore PostDoc, Japan Society for Promotion of Science (JSPS), Bioresource Center, RIKEN Institute, Tsukuba, Giappone.

-Febraio 2013-Maggio 2016: Ricercatore PostDoc, Università di Teramo, Teramo,Italy.

-Gennaio 2011: Pre-dottorato attività di ricerca, National Research Institute of Animal Reproduction, Department of Biotechnology of Animal Reproduction, Balice, Polonia.

-Aprile-Novembre 2010: Pre-dottorato attività di ricerca, Università di Napoli, Federico II, Portici, Italia.  

-Agosto 2010: Pre-dottorato attività di ricerca, Department of Experimental Embryology, Institute of Genetics and Animal Breeding (IGHZ), Jastrzębiec, Polonia.

Revisore di Progetti di Ricerca.

Czech Science Foundation, 2022

Associate Professor in Anatomy of Domestic Animals at the Department of Veterinary Sciences, University of Teramo. His scientific experience in Italian and foreign research laboratories describes Professor Domenico Iuso as a multidisciplinary researcher interested in the morpho-functional implications determined by epigenetic modifications. Research interest: studying the epigenetic dynamics that direct cellular, morphological and functional differentiation during embryo development.

Education

2022 Associate Professor in Animal Anatomy, Department of Veterinary Science, University of Teramo, Teramo, Italy

2021 Italian National Scientific Qualification for Associate Professor of Veterinary Anatomy and Physiology (07/H1)

2009-2012: PhD in Experimental Embryology, (14.11.2012), University of Teramo, Italy.

2007-2009: MSc in Biotechnologies of Reproduction (12.10.2009), University of Teramo, Italy.

2004-2007: BSc Biotechnologies (08.10.2007), University of Teramo, Italy.

Research activity

-October 2022-current position: Associate Professor in Anatomy of Domestic Animals, University of Teramo, Teramo, Italy –Department of Veterinary Sciences.

-April 2017- February 2022: Postdoctoral Researcher Fellow, Institute for Advanced Biosciences (IAB), University of Grenoble Alpes, Grenoble, France - Institute of Structural Biology (IBS), Grenoble, France.

-January 2016- March 2017: Postdoctoral Fellowship, Japan Society for Promotion of Science (JSPS), Bioresource Center, RIKEN Institute, Tsukuba, Japan.

-February 2013-May 2016: Postdoctoral Fellow, University of Teramo, Teramo, Italy.

-January 2011: Pre-doctoral International Scholarship, National Research Institute of Animal Reproduction, Department of Biotechnology of Animal Reproduction, Balice, Poland.

-April-November 2010: Pre-doctoral International Scholarship, University of Naples, Federico II, Portici, Italy. Karyotype analysis by fluorescent chromosomal probes. (Supervisor Prof. Dino Di Berardino).

-August 2010: Pre-doctoral International Scholarship, Department of Experimental Embryology, Institute of Genetics and Animal Breeding (IGHZ), Jastrzębiec, Poland.

Research Project Reviewer

Czech Science Foundation, 2022

• Ielasi FS, Ternifi S, Fontaine E, Iuso D, Couté Y, Palencia A. Human histone pre-mRNA assembles histone or canonical mRNA-processing complexes by overlapping 3'-end sequence elements Nucleic Acids Res. 2022 Nov 30:gkac878. doi: 10.1093/nar/gkac878.
• Chabert C, Vitte AL, Iuso D, Chuffart F, Trocme C, Buisson M, Poignard P, Lardinois B, Debois R, Rousseaux S, Pepin JL, Martinot JB, Khochbin S. AKR1B10, One of the Triggers of Cytokine Storm in SARS-CoV2 Severe Acute Respiratory Syndrome. Int J Mol Sci. 2022 Feb 8;23(3):1911.
• Palazzese L, Czernik M, Iuso D, Toschi P, Loi P. Nuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts.PLoS One. 2018 Mar 15;13(3):e0193954. 
• Anzalone DA, Palazzese L, Iuso D, Martino G, Loi P. Freeze-dried spermatozoa: An alternative biobanking option for endangered species.Anim Reprod Sci. 2018 Mar;190:85-93. 
• Anzalone DA, Sampino S, Czernik M, Iuso D, Ptak GE. Polychlorinated biphenyls (PCBs) alter DNA methylation and genomic integrity of sheep fetal cells in a simplified in vitro model of pregnancy exposure.Toxicol In Vitro. 2018 Feb;46:39-46. 
• Czernik M, Toschi P, Zacchini F, Iuso D, Ptak GE Deregulated Expression of Mitochondrial Proteins Mfn2 and Bcnl3L in Placentae from Sheep Somatic Cell Nuclear Transfer (SCNT) Conceptuses.PLoS One. 2017 11 January;12(1): 
• Czernik M, Iuso D^#, Toschi P, Khochbin S, Loi P. Remodeling somatic nuclei via exogenous expression of protamine 1 to create spermatid-like structures for somatic nuclear transfer.Nat Protoc. 2016 Nov;11(11):2170-2188. #Co-first author
• Loi P, Iuso D, Czernik M, Ogura A. A New, Dynamic Era for Somatic Cell Nuclear Transfer?Trends Biotechnol. 2016 Oct;34(10):791-797.
• Anzalone DA, Iuso D^#, Czernik M, Ptak G, Loi P. Plasma membrane and acrosome loss before ICSI is required for sheep embryonic development.J Assist Reprod Genet. 2016 Jun;33(6):757-63. #Co-first author
• Iuso D, Czernik M, Toschi P, Fidanza A, Zacchini F, Feil R, Curtet S, Buchou T, Shiota H, Khochbin S, Ptak GE, Loi P. Exogenous Expression of Human Protamine 1 (hPrm1) Remodels Fibroblast Nuclei into Spermatid-like Structures.Cell Rep. 2015 1 December;13(9):1765-71.
• Iuso D, Czernik M, Zacchini F, Ptak G, Loi P. A simplified approach for oocyte enucleation in mammalian cloning.Cell Reprogram. 2013 Dec;15(6):490-4. 
• Loi P, Iuso D, Czernik M, Zacchini F, Ptak G. Towards storage of cells and gametes in dry form.Trends Biotechnol. 2013 Dec;31(12):688-95. 
• Loi P, Czernik M, Zacchini F, Iuso D, Scapolo PA, Ptak G. Sheep: the first large animal model in nuclear transfer research.Cell Reprogram. 2013 Oct;15(5):367-73. 
• Iuso D, Czernik M, Di Egidio F, Sampino S, Zacchini F, Bochenek M, Smorag Z, Modlinski JA, Ptak G, Loi P. Genomic stability of lyophilized sheep somatic cells before and after nuclear transfer.PLoS One. 2013;8(1):e51317. 
• Zacchini F, Czernik M, Iuso D, Toschi P, di Egidio F, Scapolo PA, Loi P, Ptak G. Efficient production and cellular characterization of sheep androgenetic embryos.Cell Reprogram. 2011 Dec;13(6):495-502.